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Sarcoma SACT Regimens

Dacarbazine (1.2 g/m2) Therapy –21 day

Regimen

Indication

00511a

Treatment of metastatic soft tissue sarcoma.

DOXOrubicin (25mg/m2/day and CISplatin (100mg/m2) Therapy-21 day cycle

Regimen

Indication

00420a

Neoadjuvant/Adjuvant therapy of osteosarcoma.

DOXOrubicin (60) and Ifosfamide Therapy

Regimen

Indication

00391a

Treatment of locally advanced unresectable or metastatic soft tissue sarcomas.

DOXOrubicin (75) and Ifosfamide Therapy

Regimen

Indication

00392a

Neoadjuvant treatment of high risk soft tissue sarcoma.

00392b

Treatment of locally advanced unresectable or metastatic soft tissue sarcomas.

DOXOrubicin 75mg/m2 Monotherapy

Regimen

Indication

00500a

Treatment of locally advanced unresectable or metastatic soft tissue sarcoma.

eriBULin Monotherapy

Regimen

Indication

00228b

Treatment of adult patients with unresectable liposarcoma who have received prior anthracycline containing therapy (unless unsuitable) for advanced or metastatic disease.

Gemcitabine and DOCEtaxel Therapy - 21 day Therapy

Regimen

Indication

00501a

Treatment of locally advanced unresectable or metastatic soft tissue sarcoma.

Etoposide and ifosfamide - vinCRIStine, DOXOrubicin and cyclophosphamide (IE-VAC) Therapy – Two Weekly Intervals

Regimen

Indication

00675a

For the treatment of adolescents/young adults with newly diagnosed Ewing Sarcoma/ Ewing Family of tumours.

00675b

For the treatment of adolescents/young adults with rhabdomyosarcoma or desmoplastic intra-abdominal small round blue cell tumour.

Etoposide and ifosfamide - vinCRIStine, DOXOrubicin and cyclophosphamide (IE-VAC) Therapy – Three Weekly Intervals

Regimen

Indication

00747a

For the treatment of adult patients with newly diagnosed Ewing Sarcoma/ Ewing Family of tumours.

00747b

For the treatment of adult patients with rhabdomyosarcoma or desmoplastic intra-abdominal small round blue cell tumour.

Ifosfamide Etoposide (IE) Therapy

Regimen

Indication

00596a

For the treatment of relapsed Ewing Sarcoma.

00596b

For the treatment of osteosarcoma.

High Dose Ifosfamide Therapy- 21 day

Regimen

Indication

00680a

Recurrent and Primary Refractory Ewing Sarcoma.

00680b

Relapsed osteosarcoma.

Irinotecan and Temozolomide Therapy- 21 days

Regimen

Indication

00504a

Treatment of patients with relapsed/refractory Ewing’s sarcoma.

Ifosfamide, vinCRIStine, DOXOrubicin, DACTINomycin (IVADo) Therapy

Regimen

Indication

00754a

For the treatment of rhabdomyosarcoma in high / very high risk patients less than 40 years of age.

Imatinib Therapy-GIST

Regimen

Indication

00335a

Treatment of adult patients with Kit (CD117) positive unresectable and/or metastatic malignant gastrointestinal stromal tumours (GIST).

00335b

Adjuvant treatment of adult patients who are at significant risk of relapse following resection of Kit (CD117)-positive GIST.

MAP Therapy - Methotrexate (12000mg/m2) DOXOrubicin (37.5mg/m2/day) and CISplatin (60mg/m2) Therapy

Regimen

Indication

00463a

Neoadjuvant/Adjuvant therapy of localised or metastatic high grade osteosarcoma of an extremity/axial skeleton (excluding craniofacial sites)  -all disease sites amenable to complete surgical resection.

Mifamurtide Therapy

Regimen

Indication

00100a

Treatment of high-grade resectable non-metastatic osteosarcoma after macroscopically complete surgical resection, in children, adolescents and young adults.

PAZOPanib Therapy

Regimen

Indication

00445b

Treatment of adult patients with selective subtypes of advanced Soft Tissue Sarcoma (STS) who have received prior chemotherapy for metastatic disease or who have progressed within 12 months after (neo) adjuvant therapy.

Pegylated Liposomal DOXOrubicin 50mg/m2 28 days

Regimen

Indication

00205c

Metastatic soft tissue sarcoma.

Pegylated Liposomal DOXOrubicin 20mg/m2 - 21 days

Regime

Indication

00462a

Treatment of AIDS-related Kaposi’s sarcoma (KS) in patients with low CD4 counts ( < 200 CD4 lymphocytes/mm3) and extensive mucocutaneous or visceral disease.

Regorafenib Monotherapy

Regimen

Indication

00244b

Treatment of adult patients with unresectable or metastatic gastrointestinal stromal tumours (GIST) who progressed on or are intolerant to prior treatment with imatinib and sunitinib.

SUNitinib 50mg Therapy – 42 days

Regimen

Indication

00325a

Treatment of unresectable and/or metastatic malignant gastrointestinal stromal tumour (GIST) in adults after failure of imatinib treatment due to resistance or intolerance.

SUNitinib 50mg Therapy (21 days)

Regimen

Indication

00719a

Treatment of unresectable and/or metastatic malignant gastrointestinal stromal tumour (GIST) in adults after failure of imatinib treatment due to resistance or intolerance.

Trabectedin Monotherapy

Regimen

Indication

00374a

Treatment of adult patients with advanced soft tissue sarcoma, after failure of anthracyclines and ifosfamide, or who are unsuited to receive these agents.

vinBLAStine and Methotrexate Therapy

Regimen

Indication

00554a

Treatment of advanced aggressive fibromatosis.

vinCRIStine, Irinotecan and Temozolomide (VIT) Therapy

Regimen

Indication

00757a

For the treatment of relapsed/refractory rhabdomyosarcoma in adults.