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Plasma Cell Disorders SACT Regimens

Multiple Myeloma (MM)

Bortezomib and dexAMETHasone Therapy

Regimen

Indication

00270a

Treatment of adult patients with progressive multiple myeloma who have received at least one prior therapy.

Bortezomib Maintenance Therapy - 14 day

Regimen

Indication

00435a

Maintenance treatment for patients with high risk multiple myeloma

Bortezomib, Lenalidomide and dexAMETHasone (RVD) Therapy-21 day

Regimen

Indication

00416a

Treatment of newly diagnosed myeloma in adult patients with high risk features.

00416b

Treatment of relapsed or refractory myeloma that has received prior therapy in adult patients with high risk features.

Bortezomib, Lenalidomide and dexAMETHasone (RVD) Therapy- 28 day

Regimen

Indication

00643a

Treatment of Myeloma

Bortezomib, Melphalan and prednisoLONE Therapy

Regimen

Indication

00275a

Treatment of adult patients with previously untreated multiple myeloma who are not eligible for high-dose chemotherapy with haematopoietic stem cell transplantation.

Bortezomib, Lenalidomide and dexAMETHasone (RVD-Lite) Induction Therapy

Regimen

Indication

00780a

Treatment of newly diagnosed multiple myeloma patients who are transplant ineligible.

Bortezomib and Lenalidomide (RVD-Lite) Consolidation Therapy

Regimen

Indication

00781a

Treatment of newly diagnosed multiple myeloma patients who are transplant ineligible after completion of RVD-lite induction therapy.

Lenalidomide Maintenance Therapy (RVD-Lite)

Regimen

Indication

00782a

Indicated as single agent maintenance therapy in patients with newly diagnosed multiple myeloma patients who are transplant ineligible after completion of RVD-lite induction and consolidation therapy.

Bortezomib, Thalidomide and dexAMETHasone (VTD) Induction Therapy

Regimen

Indication

00274a

Bortezomib, thalidomide and dexAMETHasone for induction treatment of adult patients with previously untreated multiple myeloma who are eligible for high-dose chemotherapy with haematopoietic stem cell transplantation.

Carfilzomib and dexAMETHasone (Kd) Therapy-28day

Regimen

Indication

00566a

Carfilzomib in combination with dexAMETHasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy

Carfilzomib (20/70mg/m2 once Weekly) dexAMETHasone (Kd) Therapy-28 day

Regimen

Indication

00595a

Carfilzomib in combination with dexAMETHasone is indicated for
the treatment of adult patients with multiple myeloma who
have received at least one prior therapy

Carfilzomib (56mg/m2 once weekly) Lenalidomide and dexAMETHasone (KRd) Therapy - 28 day

Regimen

Indication

00598a

Carfilzomib, lenalidomide and dexAMETHasone therapy is indicated for the treatment of adult patients with multiple myeloma who have received at least one prior therapy.

Carfilzomib (27mg/m2 twice weekly), Lenalidomide and dexAMETHasone (KRd) Therapy - 28 day

Regimen

Indication

00405a

Carfilzomib, lenalidomide and dexAMETHasone therapy is indicated for the treatment of adult patients with multiple myeloma who have received at least one prior therapy

CyBorD/ cycloPHOSphamide, Bortezomib, and dexAMETHasone-21 day Therapy

Regimen

Indication

00273a

Treatment of newly diagnosed symptomatic multiple myeloma

00273b

Treatment of relapsed/refractory multiple myeloma

Modified CyBord/ Bortezomib/ cycloPHOSphamide and dexAMETHasone – weekly therapy

Regimen

Indication

00299a

Treatment of newly diagnosed symptomatic multiple myeloma.

00299b

Treatment of relapsed/refractory multiple myeloma.

Daratumumab Monotherapy

Regimen

Indication

00426a

As monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma whose prior therapy included a proteasome inhibitor and an immunomodulatory agent and who have demonstrated disease progression on the last therapy.

Daratumumab S/C Monotherapy

Regimen

Indication

00604a

As monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma, whose prior therapy included a proteasome inhibitor and an immunomodulatory agent and who have demonstrated disease progression on the last therapy

Daratumumab (IV), Bortezomib and dexAMETHasone Therapy

Regimen

Indication

00560a

Daratumumab in combination with bortezomib and dexAMETHasone in adult patients with multiple myeloma who have received at least one prior therapy

Daratumumab (SC 1800mg), Bortezomib and dexAMETHasone Therapy

Regimen

Indication

00609a

Daratumumab in combination with bortezomib and dexAMETHasone in adult patients with multiple myeloma who have received at least one prior therapy

Daratumumab (SC 1800mg), Bortezomib (weekly) and dexAMETHasone Therapy

Regimen

Indication

00695a

Daratumumab in combination with bortezomib and dexAMETHasone in adult patients with multiple myeloma who have received at least one prior therapy

Daratumumab SC, Bortezomib, Thalidomide and dexAMETHasone Induction Therapy

Regimen

Indication

00703a

Daratumumab in combination with bortezomib, thalidomide and dexAMETHasone for the treatment of adults with newly diagnosed multiple myeloma who are eligible for autologous stem cell transplant

Daratumumab SC, Bortezomib, Thalidomide and dexAMETHasone Consolidation Therapy

Regimen

Indication

00755a

Daratumumab in combination with bortezomib, thalidomide and dexAMETHasone for the treatment of adults with newly diagnosed multiple myeloma who are eligible for autologous stem cell transplant

Daratumumab (SC), Bortezomib (Once Weekly), Thalidomide and dexAMETHasone Induction Therapy

Regimen

Indication

00752a

Daratumumab in combination with bortezomib, thalidomide and dexAMETHasone for the treatment of adults with newly diagnosed multiple myeloma who are eligible for autologous stem cell transplant

Daratumumab (SC), Bortezomib (Once Weekly), Thalidomide and dexAMETHasone Consolidation Therapy

Regimen

Indication

00756a

Daratumumab in combination with bortezomib, thalidomide and dexAMETHasone for the treatment of adults with newly diagnosed multiple myeloma who are eligible for autologous stem cell transplant

Elranatamab Monotherapy

Regimen

Indication:

00917a

As monotherapy for the treatment of adult patients with relapsed and refractory (R/R) multiple myeloma (MM), who have received at least three prior therapies including an immunomodulatory agent (IMiD), a proteasome inhibitor (PI) and an anti-cluster of differentiation 38 (anti-CD38) antibody and have demonstrated disease progression on the last therapy.

Ixazomib, Lenalidomide and dexAMETHasone Therapy - 28 day

Regimen

Indication

00516a

Ixazomib in combination with lenalidomide and dexAMETHasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy

Lenalidomide 25mg and dexAMETHasone Therapy-28 day

Regimen

Indication

00218a

Treatment of adult patients with previously untreated multiple myeloma who are not eligible for transplant.

00218b

Treatment of multiple myeloma in adult patients who have received at least one prior therapy.

Pomalidomide and dexAMETHasone

Regimen

Indication

00245a

Treatment in combination with dexAMETHasone of adult patients with relapsed and refractory multiple myeloma who have received at least two prior treatment regimens, including both lenalidomide and bortezomib, and have demonstrated disease progression on the last therapy.

Pomalidomide, Bortezomib and dexAMETHasone (PVD) Therapy

Regimen

Indication

00601a

Pomalidomide in combination with bortezomib and dexAMETHasone for the treatment of adult patients with multiple myeloma who have received at least one prior treatment including lenalidomide

Pomalidomide, Bortezomib (Once weekly) and dexamethasone (PVD) - 28 day Therapy

Regimen

Indication

00880a

Pomalidomide in combination with bortezomib and dexAMETHasone for the treatment of adult patients with multiple myeloma who have received at least one prior treatment including lenalidomide

Bortezomib, dexAMETHasone, Thalidomide, CISplatin, DOXOrubicin, cycloPHOSphamide and Etoposide (VDT PACE) Therapy

Regimen

Indication

00496a

Failure to achieve response or disease progression with induction therapy in patients with multiple myeloma.

00496b

Relapsed or refractory myeloma patients suitable for intensive salvage chemotherapy.

00496c

Treatment of multiple myeloma in patients with primary plasma cell leukaemia or initial presentation with extra-medullary disease.

Daratumumab SC, Lenalidomide and dexAMETHasone Therapy

Regimen

Indication

00854a

Daratumumab in combination with lenalidomide and dexAMETHasone for the treatment of adult patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant.

Talquetamab Monotherapy (biweekly)

Regimen

Indication

00914a

As monotherapy for the treatment of adult patients with relapsed and refractory (R/R) multiple myeloma (MM), who have received at least three prior therapies including an immunomodulatory agent (IMiD), a proteasome inhibitor (PI) and an anti-cluster of differentiation 38 (anti-CD38) antibody and have demonstrated disease progression on the last therapy.

Teclistamab Monotherapy

Regimen

Indication

00865a

As monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma, who have received at least three prior therapies, including and immunomodulatory agent, a proteasome inhibitor and an anti-CD38 antibody and have demonstrated disease progression on the last therapy.

Teclistamab Monotherapy - Two Weekly Maintenance

Regimen

Indication

00927a

As monotherapy for the treatment of adult patients with relapsed and refractory multiple myeloma, who have received at least three prior therapies, including an immunomodulatory agent, a proteasome inhibitor and an anti-CD38 antibody and have demonstrated disease progression on the last therapy.

Amyloidosis

Daratumumab, Bortezomib, cycloPHOSphamide and dexAMETHasone (D-VCd) Therapy

Regimen

Indication

00779a

Daratumumab in combination with bortezomib, cycloPHOSphamide and dexAMETHasone (D-VCd) for the treatment of adult patients with newly diagnosed light chain (AL) amyloidosis.

AL Amyloidosis: cycloPHOSphamide, Bortezomib and dexAMETHasone (CVD) 28 Day Therapy

Regimen

Indication

00652a

Treatment of newly diagnosed systemic AL amyloidosis

00652b

Treatment of relapsed/refractory systemic AL amyloidosis

Plasma Cell Disorder Other (Mobilisation of peripheral blood stem cells, conditioning regimens for MM and plasma Cell dyscrasia)

cycloPHOSphamide 2000mg/m2 For Stem Cell Mobilisation

Regimen

Indication

00438a

Mobilisation of peripheral blood stem cells for future stem cell rescue following high dose chemotherapy

cycloPHOSphamide 1500mg/m2 For Stem Cell Mobilisation

Regimen

Indication

00795a

Mobilisation of peripheral blood stem cells for future stem cell rescue following high dose chemotherapy.

High Dose Melphalan Conditioning Therapy for Autologous Stem Cell Transplant

Regimen

Indication

00454a

Conditioning Therapy in patients with Multiple Myeloma prior to autologous stem cell transplant

00454b

Conditioning Therapy in patients with other plasma cell dyscrasia such as AL amyloidosis

Plerixafor and G-CSF Therapy

Regimen

Indication

00536a

Is indicated in combination with granulocyte-colony stimulating factor (G-CSF) to enhance mobilisation of haematopoietic stem cells to the peripheral blood for collection and subsequent autologous transplantation in adult patients with lymphoma and multiple myeloma whose cells mobilise poorly