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Head and Neck SACT Regimens

CARBOplatin (AUC 5) and 5-Fluorouracil 1000mg/m2/day Therapy – 28 day cycle

Regimen

Indication

00552a

Adjuvant chemotherapy following chemoradiation treatment in patients with locally advanced stage III or IV nasopharyngeal carcinoma where CISplatin is contraindicated or not tolerated.

CARBOplatin AUC4 and 5-Fluorouracil 600mg/m2 with Radiotherapy

Regimen

Indication

00591a

Locally Advanced Squamous Cell Carcinoma of the Head and Neck.

CARBOplatin 70mg/m2 and 5-Fluorouracil 600mg/m2 with Radiotherapy

Regimen

Indication

00589a

Locally Advanced Squamous Cell Carcinoma of the Head and Neck.

CARBOplatin (AUC4-6) Monotherapy-21 days

Regimen

Indication

00261

Chemoradiation treatment for locally advanced (stage III to IV) squamous cell carcinoma (SCC) of the head and neck, where treatment with CISplatin is not appropriate (AUC 5).

CARBOplatin (AUC2) Weekly with Radiotherapy (RT)

Regimen

Indication

00419a

Chemoradiation treatment of stage III and IV locally advanced nasopharyngeal carcinoma in patients where CISplatin is contraindicated or not tolerated.

CARBOplatin AUC (1.5) Chemoradiation Therapy-7 days

Regimen

Indication

00332a

Chemoradiation commencing 3 to 8 weeksafter the completion of induction chemotherapy with TPF in patients with Stage III or IV locally advanced squamous cell carcinoma (SCC) of the head and neck.

Cetuximab (weekly), Carboplatin AUC 5 and 5-Fluorouracil 1000mg/m2/day Therapy-21 day cycle

Regimen

Indication

00418a

Locally advanced or metastatic squamous cell head and neck cancer where CISplatin is contraindicated or not tolerated.

Cetuximab (weekly), CISplatin 100mg/m2 and 5-Fluorouracil 1000mg/m2/day Therapy- 21 day cycle

Regimen

Indication

00417a

Locally advanced or metastatic squamous cell carcinoma of the head and neck.

Cetuximab Therapy-7 days

Regimen

Indication

00207b

Treatment of patients with squamous cell cancer of the head and neck: In combination with radiation therapy for locally advanced disease.

CISplatin 100mg/m2 with Radiotherapy (RT)

Regimen

Indication

00387a

Chemoradiation treatment for locally advanced (stage III to IV) squamous cell carcinoma (SCC) of the head and neck.

CISplatin 40mg/m2 Weekly with Radiotherapy (RT)

Regimen

Indication

00385c

Chemoradiation treatment for locally advanced nasopharnygeal carcinoma.

00385d

Chemoradiation treatment for locally advanced unresectable head and neck squamous carcinoma (SCC) in patients who cannot tolerate three weekly CISplatin regimens.

CISplatin and 5-Fluorouracil Therapy-28 day cycle

Regimen

Indication

00314a

Locally advanced or metastatic head and neck cancer.

cycloPHOSphamide, DOXOrubicin and CISplatin Therapy-21 Day

Regimen

Indication

00615a

Treatment of advanced salivary gland cancer.

DOCEtaxel (75), CISplatin (75), 5-Fluorouracil (750) (TCF) and Radiotherapy

Regimen

Indication

00324a

Induction treatment followed by radiotherapy of patients with Stage III or IV non-metastatic squamous cell carcinoma of the head and neck.

DOCEtaxel (75), CISplatin (100) and 5-Fluorouracil (1000) (TCF) Chemoradiation (Induction) Therapy

Regimen

Indication

00323a

Induction treatment of patients with locally advanced Stage III or IV non-metastatic squamous cell carcinoma of the head and neck.

Gemcitabine (1250mg/m2) and CISplatin (80mg/m2) Therapy-21 day

Regimen

Indication

00517a

Treatment of locally advanced nasopharyngeal cancer

Gemcitabine (1000mg/m2) and CISplatin (80mg/m2) Induction Therapy

Regimen

Indication

00903a

Induction chemotherapy prior to concurrent chemo-radiotherapy for loco-regionally advanced nasopharyngeal carcinoma.

Gemcitabine (1250mg/m2) Monotherapy- 21 day

Regimen

Indication

00514a

Loco-regionally recurrent/metastatic nasopharyngeal cancer not amenable for local curative therapy.

Lenvatinib_DTC Therapy

Regimen

Indication

00295a

Treatment of adult patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hürthle cell) thyroid carcinoma (DTC), refractory to radioactive iodine.

DOCEtaxel (75), CISplatin (75), 5-Fluorouracil (1000) - Induction/Neoadjuvant (TPF)

Regimen

Indication

00315a

Induction treatment of patients with Stage III or IV non-metastatic squamous cell carcinoma of the head and neck.

Methotrexate 40mg/m2 Monotherapy - 28 Day

Regimen

Indication

00893a

Recurrent, advanced or metastatic head and neck squamous cell carcinoma (SCC) in patients with comorbidities or as palliative treatment in patients unsuitable for combination chemotherapy

Nivolumab Monotherapy - 14 day

Regimen

Indication

00483d

As monotherapy for the treatment of squamous cell cancer of the head and neck in adults progressing on or after platinum-based therapy.

Nivolumab Monotherapy - 28 day

Regimen

Indication

00484e

As monotherapy for the treatment of squamous cell cancer of the head and neck in adults progressing on or after platinum-based therapy.

PACLitaxel (Day 1, 8 and 15) and Cetuximab (Day 1 and 15) Therapy- 28 day

Regimen

Indication

00696a

For the treatment of patients with recurrent and / or metastatic squamous cell carcinoma of the head and neck

Pembrolizumab 200mg Monotherapy

Regimen

Indication

00455h

As monotherapyfor the first-line treatment of metastatic or unresectable recurrent head and neck squamous cell carcinoma (HNSCC) in adults whose tumours express PD-L1 with a CPS ≥ 1.

Pembrolizumab 400mg Monotherapy

Regimen

Indication

00558h

As monotherapyfor the first-line treatment of metastatic or unresectable recurrent head and neck squamous cell carcinoma (HNSCC) in adults whose tumours express PD-L1 with a CPS ≥ 1.

Pembrolizumab, CARBOplatin (AUC 5) and 5- Fluorouracil Therapy

Regimen

Indication

00705a

Pembrolizumab is indicated, in combination with CARBOplatin and 5- fluorouracil, for the first-line treatment of metastatic or unresectable recurrent head and neck squamous cell carcinoma (HNSCC) in adults whose tumours express PD-L1 with a CPS ≥ 1.

Pembrolizumab, CISplatin and 5- Fluorouracil Therapy

Regimen

Indication

00706a

Pembrolizumab is indicated, in combination with CISplatin and 5-fluorouracil, for the first-line treatment of metastatic or unresectable recurrent head and neck squamous cell carcinoma (HNSCC) in adults whose tumours express PD-L1 with a CPS ≥ 1.

SORAfenib Therapy

Regimen

Indication

00294c

Treatment of patients with progressive, locally advanced or metastatic differentiated (papillary/follicular/Hürthle cell) thyroid carcinoma, refractory to radioactive iodine.

Vandetanib Monotherapy

Regimen

Indication

00242a

Treatment of aggressive and symptomatic MTC in patients with unresectable locally advanced or metastatic disease