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Chronic Lymphocytic Leukaemia (CLL) and Hairy Cell Leukaemia (HCL) SACT Regimens

Acalabrutinib (Tablets) Monotherapy

Regimen

Indication

00840a

As monotherapy is indicated for the treatment of adult patients with chronic lymphocytic leukaemia (CLL) who have received at least one prior therapy

00840b

As monotherapy for the treatment of previously untreated CLL in the presence of 17p deletion or TP53 mutation in adult patients unsuitable for chemoimmunotherapy

Bendamustine Monotherapy

Regimen

Indication

00527a

Treatment of patients with relapsed or refractory Chronic Lymphocytic Leukaemia (CLL)

Chlorambucil 10mg/m2 Therapy

Regimen

Indication

00411b

Treatment of patients with Chronic Lymphocytic Leukaemia

Fludarabine, cycloPHOSphamide and riTUXimab ( FC (IV) and R) Therapy

Regimen

Indication

00241a

Treatment of B-cell chronic lymphocytic leukaemia (CLL).

Ibrutinib Therapy-CLL - Waldenström’s macroglobulinaemia

Regimen

Indication

00296a

As a single agent for the treatment of adult patients with chronic lymphocytic leukaemia (CLL) who have received at least one prior therapy.

00296b

As a single agent for the treatment of adult patients with chronic lymphocytic leukaemia (CLL) in first line in the presence of 17p deletion or TP53 mutation in patients unsuitable for chemo-immunotherapy.

Idelalisib and riTUXimab Therapy

Regimen

Indication

00389a

In combination with riTUXimab for the treatment of adult patients with chronic lymphocytic leukaemia (CLL) who have received at least one prior therapy

00389b

In combination with riTUXimab for the treatment of adult patients with chronic lymphocytic leukaemia (CLL) as first line treatment in the presence of 17p deletion or TP53 mutation in patients who are not eligible for any other therapies

Obinutuzumab and Chlorambucil Therapy

Regimen

Indication

00286a

Treatment of adult patients with previously untreated chronic lymphocytic leukaemia (CLL) and with comorbidities making them unsuitable for full-dose fludarabine based therapy.

Venetoclax Monotherapy

Regimen

Indication

00400a

Treatment of chronic lymphocytic leukaemia (CLL) in the presence of 17p deletion or TP53 mutation in adult patients who are unsuitable for or have failed a B-cell receptor pathway inhibitor.

00400b

Treatment of CLL in the absence of 17p deletion or TP53 mutation in adult patients who have failed both chemoimmunotherapy and a B-cell receptor pathway inhibitor

Venetoclax and Obinutuzumab Therapy

Regimen

Indication

00715a

In combination with obinutuzumab for the treatment of adult patients with previously untreated chronic lymphocytic leukaemia (CLL).

Venetoclax and riTUXimab Therapy

Regimen

Indication

00575a

Venetoclax in combination with riTUXimab is indicated for the treatment of adult patients with chronic lymphocytic leukaemia (CLL) who have received at least one prior therapy

Zanubrutinib Therapy

Regimen

Indication

00708b

As monotherapy for the treatment of adult patients with chronic lymphocytic leukaemia (CLL), who are treatment naïve and have del(17p) and/or TP53-mutated disease

00708c

As monotherapy for the treatment of adult patients with CLL, who have relapsed and/or refractory disease following at least one line of prior therapy

Cladribine 0.14mg/day Day 1 to 5 Therapy

Regimen

Indication

00402a

First line treatment for adult patients with Hairy Cell Leukaemia

Cladribine 0.14mg/day Day 1 to 5 Therapy

Regimen

Indication

00469a

First line treatment for adult patients with Hairy Cell Leukaemia

Cladribine Weekly and riTUXimab Therapy

Regimen

Indication

00534a

Treatment for adult patients with relapsed or partially responsive Hairy Cell Leukaemia.

Cladribine 5 day and riTUXimab Therapy

Regimen

Indication

00531a

Treatment for adult patients with relapsed or partially responsive Hairy Cell Leukaemia.